{"id":38,"date":"2015-07-09T16:47:17","date_gmt":"2015-07-09T20:47:17","guid":{"rendered":"https:\/\/permegear.com\/?page_id=38"},"modified":"2019-01-29T09:29:43","modified_gmt":"2019-01-29T13:29:43","slug":"diffusion-101","status":"publish","type":"page","link":"https:\/\/permegear.com\/diffusion-101\/","title":{"rendered":"Diffusion 101"},"content":{"rendered":"<h3>Introduction<\/h3>\n<p>If diffusion studies are new to you, perhaps you\u2019ve been assigned one and you have no idea where to begin, please read\u00a0<a href=\"https:\/\/permegear.com\/wp-content\/uploads\/2017\/10\/Diffusion-Cell-Basics.pdf\">Diffusion Cell Basics\u00a0<\/a>for\u00a0terms, definitions and background information.\u00a0 Once you have an idea of how to proceed but feel some additional guidance would be helpful, you can download our\u00a0<a href=\"https:\/\/permegear.com\/wp-content\/uploads\/2015\/08\/primer.pdf\">Diffusion Testing Fundamentals<\/a>\u00a0primer to help you learn what is required for a proper study and begin to design one.\u00a0For\u00a0comprehensive\u00a0membrane\u00a0and selection guidance, please view the following documents:<\/p>\n<ul>\n<li><a href=\"https:\/\/permegear.com\/wp-content\/uploads\/2017\/12\/PermeGears-Guide-to-Choosing-a-Membrane.pdf\">PermeGear&#8217;s Guide To Choosing A Membrane<\/a><\/li>\n<li><a href=\"https:\/\/permegear.com\/wp-content\/uploads\/2019\/01\/Membrane-Table-1-Materials.pdf\">Membrane Films<\/a><\/li>\n<li><a href=\"https:\/\/permegear.com\/wp-content\/uploads\/2017\/09\/Membrane-Table-2-Filters.pdf\">Membrane Filters<\/a><\/li>\n<li><a href=\"https:\/\/permegear.com\/wp-content\/uploads\/2017\/09\/Membrane-Table-3-Dialysis.pdf\">Membrane Dialysis<\/a><\/li>\n<\/ul>\n<p>For further assistance, please email us at: <a href=\"mailto:support@permegear.com\">support@permegear.com<\/a><\/p>\n<h3>Basics for Ordering<\/h3>\n<p>If you plan to use Franz Cells and you\u2019re not sure how to proceed, here are some practical basics to consider:<\/p>\n<ul>\n<li>1 &#8211; Franz Cell experiments are generally run at an elevated temperature. You can use your Franz Cells in an incubated environment, or you can purchase jacketed cells and connect them to a source of warming water, a water bath and pump, or heater\/circulator. Jacketed cells are more expensive, but using them out of an incubated hood is less cumbersome especially in a <a href=\"https:\/\/permegear.com\/v-series\/\">V-Series Stirrer<\/a>.<\/li>\n<li>2 &#8211; What orifice diameter is best? For human skin, 9mm is strongly recommended because it&#8217;s large enough to provide reliable data but small enough to accommodate skin specimens that aren\u2019t too costly. For mucosa, 5mm is appropriate because it\u2019s often difficult to obtain specimens suitable for larger cells. For all other membranes any size orifice will do, 15mm is the most common size for polymeric membranes.<\/li>\n<li>3 &#8211; What receptor chamber volume will work? \u00a0The receptor volumes of our standard cells will provide good data for a majority of experiments. However, there are always exceptions, and we can often provide receptor chamber volumes that will generate better data for those occasions when the standard cells aren&#8217;t ideal. \u00a0It seems to hold true that the larger the ratio of the orifice area to the receptor volume, the better the results will be. \u00a0Therefore, generally, it is desirable to make the receptor chamber volumes as small as possible. (Some researchers have requested much larger than standard volume receptor chambers even so.) \u00a0If you have determined that receptor volume is critical to your work, we can likely provide a more suitable Franz Cell in the unjacketed variety as the heating jacket presents constraints where practical glassblowing is concerned. \u00a0For a given orifice diameter, it is much easier to achieve a smaller than standard receptor volume in an unjacketed cell.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Introduction If diffusion studies are new to you, perhaps you\u2019ve been assigned one and you have no idea where to begin, please read\u00a0Diffusion Cell Basics\u00a0for\u00a0terms, definitions and background information.\u00a0 Once you have an idea of how to proceed but feel some additional guidance would be helpful, you can download our\u00a0Diffusion Testing Fundamentals\u00a0primer to help you [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.7 - 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