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PermeGear, Inc. manufactures Franz Cells, Side-Bi-Side cells, and related equipment for studying membrane transport and drug diffusion through biological and synthetic membranes. Applications include experimentation in the areas of drug discovery, drug transport, drug screening, controlled release, formulation optimization, dermatology, skin toxicology, oral absorption, buccal absorption, percutaneous absorption, equilibrium dialysis, and protein binding.
The most popular application is in the development of transdermal and topical pharmaceuticals. However, our equipment is also used in basic research or preformulation projects requiring measurement of diffusion coefficients, partition coefficients, and membrane permeabilities. We provide both specialized diffusion cells for research projects, such as iontophoresis, cannabinoid testing, and automatic sampling systems for high-output measurements, such as in vitro release from topical pharmaceuticals.